Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation.
basic_science · Level V
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- Record sourced from PubMed, PMID 24747802.
- Also identified by DOI 10.1371/journal.pone.0093850 and PMC identifier 3991568.
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Abstract
DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples. The mRNA and protein levels of P16 were significantly reduced in radiation-induced thymic lymphoma tissue samples. Twenty-three CpG sites of the CpG islands in the p16 promoter region were detected, and the methylation percentages of -71, -63, -239, -29, -38, -40, -23, 46 CpG sites were significantly higher in radiation-induced thymic lymphoma tissue samples than those in matched non-irradiated thymus tissue samples. This study provides new evidence for the methylation state of p16 in the radiation-induced thymic lymphoma samples, which suggests that the methylation of these CpG sites in the p16 promoter may reduce its expression in the thymic lymphoma after irradiation.
Medical subject headings
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Methylation
- Lymphoma
- Neoplasms, Radiation-Induced
- Thymus Neoplasms