A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24753450.
- Also identified by DOI 10.1002/adhm.201400114.
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Abstract
Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.
Medical subject headings
- Drug Delivery Systems
- Retina
- Retinal Diseases