Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24759824.
- Also identified by DOI 10.1093/cid/ciu284 and PMC identifier 4990826.
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Abstract
The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.
Medical subject headings
- HIV Infections
- HIV-1
- Leukemia, Myeloid, Acute
- Receptors, CCR5
- Receptors, HIV
- Stem Cell Transplantation
- Viral Tropism