Connect four with glioblastoma stem cell factors.
basic_science · Level V
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- Record sourced from PubMed, PMID 24766799.
- Also identified by DOI 10.1016/j.cell.2014.04.001.
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Abstract
Hierarchical cell state models, wherein a few stem-like tumor-propagating cells repopulate the tumor after therapy, are often invoked in cancer. Suvà et al. demonstrate a plastic developmental hierarchy in glioma cell populations by characterizing the epigenetic states of phenotypically distinct cells and identifying four factors sufficient to reprogram differentiated cells into a tumorigenic stem-like state.
Medical subject headings
- Brain Neoplasms
- Glioblastoma
- Neoplastic Stem Cells