Large-scale de novo DNA synthesis: technologies and applications.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24781323.
- Also identified by DOI 10.1038/nmeth.2918 and PMC identifier 7098426.
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Abstract
For over 60 years, the synthetic production of new DNA sequences has helped researchers understand and engineer biology. Here we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on recent technologies that allow for large-scale and low-cost production. In addition, we discuss emerging applications enabled by large-scale de novo DNA constructs, as well as the challenges and opportunities that lie ahead.
Medical subject headings
- DNA
- Genetic Engineering