Programming biological operating systems: genome design, assembly and activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24781325.
- Also identified by DOI 10.1038/nmeth.2894.
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Abstract
The DNA technologies developed over the past 20 years for reading and writing the genetic code converged when the first synthetic cell was created 4 years ago. An outcome of this work has been an extraordinary set of tools for synthesizing, assembling, engineering and transplanting whole bacterial genomes. Technical progress, options and applications for bacterial genome design, assembly and activation are discussed.
Medical subject headings
- Genetic Engineering
- Genome, Bacterial
- Synthetic Biology
- Systems Biology