ANO1: an additional key player in cyst growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24786872.
- Also identified by DOI 10.1038/ki.2013.436.
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Abstract
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an embryonic kidney cyst model. Their results support a potential role for this chloride channel in cyst generation.
Medical subject headings
- Cell Proliferation
- Chloride Channels
- Chlorides
- Epithelial Cells
- Kidney
- Neoplasm Proteins
- Polycystic Kidney, Autosomal Dominant