Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.
Where this comes from
- Record sourced from PubMed, PMID 24786873.
- Also identified by DOI 10.1038/ki.2013.440.
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Abstract
The role of the circulating renin-angiotensin system (RAS) in regulating systemic blood pressure and sodium balance is well established. More recently, researchers have turned their focus to the local generation of angiotensin II (Ang II) in specific tissues. Matsusaka et al. revisit the renal RAS and provide evidence that liver-derived angiotensinogen (AGT) is a major determinant of renal Ang II levels in a model of podocyte injury.
Medical subject headings
- Angiotensin II
- Angiotensinogen
- Kidney Diseases
- Kidney Tubules, Proximal
- Liver
- Podocytes