Photothermal effect for localized desorption of primary lymphocytes arrayed on an antibody/DNA-based biochip.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24789691.
- Also identified by DOI 10.1039/c4lc00336e.
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Abstract
This work proposes a miniaturized system able to perform multiple cell capture followed by cell-type selective release from a biochip surface. Unlabelled lymphocytes were first specifically captured onto a DNA array by antibody-DNA conjugates. The immobilized cells were subsequently released under spatiotemporal control within local heating generated by intense Surface Plasmon Resonance (SPR) produced by laser illumination.
Medical subject headings
- Antibodies
- B-Lymphocytes
- DNA
- Surface Plasmon Resonance
- T-Lymphocytes
- Tissue Array Analysis