Diabetes, aging, and their tissue complications.
review · Level V
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- Record sourced from PubMed, PMID 24789881.
- Also identified by DOI 10.1172/JCI75224 and PMC identifier 4001559.
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Abstract
The inactivation of NO by advanced glycation endproducts (AGEs), which accumulate on tissue proteins as a function of age and hyperglycemia, focused attention on the role of these ubiquitous posttranslational modifications in acquired impairments of vascular reactivity and other signaling processes. This observation occurred during a watershed period of basic and translational research in glycation that encompassed new pathologic phenomena and novel intervention strategies. How has the AGE paradigm for the tissue complications of aging and diabetes fared since the identification of the link between these glycation products and NO inactivation, and what lessons may be offered for future investigations?
Medical subject headings
- Aging
- Diabetes Mellitus
- Glycation End Products, Advanced
- Nitric Oxide