Variety in the tumor microenvironment: integrin splicing regulates stemness.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24792112.
- Also identified by DOI 10.1016/j.stem.2014.04.011.
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Abstract
Recently in Cell Reports, Goel et al. (2014) identified mechanisms underlying cellular heterogeneity in triple negative breast cancer. They find that expression of α6 integrin and its splice variants differs between epithelial and mesenchymal tumor cell subpopulations, the latter of which relies on VEGF signaling to promote cancer stem cell function.
Medical subject headings
- Integrin alpha6
- Neoplastic Stem Cells
- RNA Splicing