The microenvironment matters: estrogen deficiency fuels cancer bone metastases.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24803577.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0576 and PMC identifier 4061908.
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Abstract
Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.
Medical subject headings
- Bone Neoplasms
- Breast Neoplasms
- Estrogens
- Osteoporosis, Postmenopausal
- Tumor Microenvironment