Obesity corrupts myelopoiesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24807218.
- Also identified by DOI 10.1016/j.cmet.2014.04.010.
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Abstract
Ongoing monocyte infiltration and subsequent macrophage seeding of adipose tissue is thought to be a key feature of obesity pathophysiology. Nagareddy et al. (2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.
Medical subject headings
- Adipose Tissue
- Macrophages
- Monocytes
- Myelopoiesis
- Obesity