Translating glycolytic metabolism to innate immunity in dendritic cells.
editorial · Level V
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- Record sourced from PubMed, PMID 24807219.
- Also identified by DOI 10.1016/j.cmet.2014.04.012 and PMC identifier 4050200.
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Abstract
Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.
Medical subject headings
- Dendritic Cells
- Glycolysis
- I-kappa B Kinase
- Protein Serine-Threonine Kinases
- T-Lymphocytes