Mast cell activation disorders.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24811013.
- Also identified by DOI 10.1016/j.jaip.2014.03.007.
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Abstract
Disorders associated with mast cell activation range from relatively common IgE-mediated disease and chronic urticaria to rarer conditions such as mastocytosis or monoclonal mast cell activation disorder. Mast cell activation disorders can be mechanistically classified into primary (associated with abnormal production of mast cells that carry pathologic markers of clonality), secondary (normal mast cells activated in reaction to a microenvironmental trigger), and idiopathic (no etiology is found). Clinical presentations, diagnostic criteria as well as general principles of a stepwise therapy approach are discussed.
Medical subject headings
- Anti-Allergic Agents
- Glucocorticoids
- Histamine Antagonists
- Immunologic Factors
- Mastocytosis