Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24811313.
- Also identified by DOI 10.1002/adhm.201400148.
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Abstract
Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.
Medical subject headings
- Anti-HIV Agents
- Biodegradable Plastics
- Drug Carriers
- HIV Infections
- HIV-1
- Prodrugs
- Zidovudine