Proliferation at the heart of preadolescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24813600.
- Also identified by DOI 10.1016/j.cell.2014.04.025.
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Abstract
Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for congenital and acquired heart diseases.
Medical subject headings
- Cell Differentiation
- Cell Proliferation
- Heart
- Myocytes, Cardiac