Deciphering functions of branched ubiquitin chains.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24813601.
- Also identified by DOI 10.1016/j.cell.2014.04.026.
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Abstract
The anaphase-promoting complex/cyclosome targets proteins for degradation by catalyzing homotypic ubiquitin chains of different linkage types. In this issue of Cell, Meyer and Rape diversify the degradation signals by demonstrating that the APC/C and its cognate E2 conjugating enzymes enhance the rate of substrate degradation by decorating them with branched Lys11 and Lys48 ubiquitin chains.
Medical subject headings
- Anaphase-Promoting Complex-Cyclosome
- Proteasome Endopeptidase Complex
- Proteolysis