Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 24813646.
- Also identified by DOI 10.1016/j.arth.2014.03.025.
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Abstract
Functional exercise after total knee arthroplasty (TKA) is necessary. However, it may be a difficult and painful process for the patient. Desirable methods of relieving the patient's pain are worth exploring. Oral supplement of adenosine triphosphate (ATP) is a potential option. In the present study, we decide to investigate whether short-term administration of ATP benefits patients undergoing TKA. A total of 244 subjects were randomized to receive 120mg ATP or placebo each day for 4weeks. Significant differences in quadriceps strength, pain scores at postoperative days 7, 14, 21, and 28 and total opioid consumption were detected. It follows that oral supplement of ATP could benefit patients recovering from TKA.
Medical subject headings
- Adenosine Triphosphate
- Arthroplasty, Replacement, Knee
- Muscle Strength
- Performance-Enhancing Substances
Anatomy
- knee