Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24816721.
- Also identified by DOI 10.1371/journal.pone.0097030 and PMC identifier 4016208.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findings indicated serological identity between the two chimpanzee polyomaviruses investigated and a high level of cross-reactivity with Merkel cell polyomavirus. In contrast, cross-reactivity was not observed between TSPyV and OraPyV1. Furthermore, specific antibodies to chimpanzee polyomaviruses were detected in chimpanzee sera by pre-incubation of sera with the different antigens, but not in human sera.
Medical subject headings
- Cross Reactions
- Pan troglodytes
- Phylogeny
- Polyomavirus
- Polyomavirus Infections