A note on exact differences between beta distributions in genomic (Methylation) studies.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24824426.
- Also identified by DOI 10.1371/journal.pone.0097349 and PMC identifier 4019606.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism presented here can be applied in a similar way to variant calling.
Medical subject headings
- DNA Methylation
- Genome
- Models, Genetic