Reining in radiation injury: HIF2α in the gut.

Lee, Chang-Lung; Moding, Everett J; Kirsch, David G · Sci Transl Med · 2014

expert_opinion · Level V

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Abstract

Deletion of prolyl hydroxylase domain proteins or overexpression of hypoxia-inducible factor 2α (HIF2α) in the gastrointestinal epithelium improves survival of mice after abdominal irradiation (Taniguchi et al., this issue).

Medical subject headings