Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies.
basic_science · Level V
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- Record sourced from PubMed, PMID 24837401.
- Also identified by DOI 10.1093/infdis/jiu289.
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Abstract
High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.
Medical subject headings
- Anti-Inflammatory Agents
- Apoptosis
- Ascomycota
- Methylprednisolone
- Mycoses