Multifunctional theranostic red blood cells for magnetic-field-enhanced in vivo combination therapy of cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24838472.
- Also identified by DOI 10.1002/adma.201400158.
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Abstract
Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded with a chemotherapeutic drug, doxorubicin, to enable imaging-guided combined photodynamic and chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise of integrating cell-based drug-delivery systems with nanotechnology as a biocompatible multifunctional platform for applications in cancer theranostics.
Medical subject headings
- Breast Neoplasms
- Doxorubicin
- Erythrocyte Transfusion
- Magnetite Nanoparticles
- Porphyrins