A stiffness-mediated oncogenic hammer.
Where this comes from
- Record sourced from PubMed, PMID 24848253.
- Also identified by DOI 10.1126/scitranslmed.3009154.
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Abstract
A recent study in Nature Medicine identified a tissue stiffness-induced microRNA that mediates oncogenic signaling; its expression stratifies luminal breast cancer survivors to predict accelerated metastatic relapse.
Medical subject headings
- Breast Neoplasms
- Extracellular Matrix
- Mechanotransduction, Cellular
- MicroRNAs
- Oncogenes