The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction.
basic_science · Level V
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- Record sourced from PubMed, PMID 24848978.
- Also identified by DOI 10.1021/nl501248y.
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Abstract
We show that the nanoscale adhesion geometry controls the spreading and differentiation of epidermal stem cells. We find that cells respond to such hard nanopatterns similarly to their behavior on soft hydrogels. Cellular responses were seen to stem from local changes in diffusion dynamics of the adapter protein vinculin and associated impaired mechanotransduction rather than impaired recruitment of proteins involved in focal adhesion formation.
Medical subject headings
- Focal Adhesions
- Mechanotransduction, Cellular
- Nanostructures
- Stem Cells
- Vinculin