The changing geometry of a fitness landscape along an adaptive walk.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24853069.
- Also identified by DOI 10.1371/journal.pcbi.1003520 and PMC identifier 4031059.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
Medical subject headings
- Adaptation, Physiological
- Epistasis, Genetic
- Evolution, Molecular
- Genetic Fitness
- Models, Genetic
- Models, Statistical
- Selection, Genetic