Focusing in on T cell cross-reactivity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24855938.
- Also identified by DOI 10.1016/j.cell.2014.05.002.
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Abstract
To provide broad immunity to a vast array of foreign antigens with a limited number of T lymphocytes, each cell has to recognize many targets. By implementing a strategy to identify T cell receptor (TCR) ligands and investigating at a fine granularity their structure and sequence relationship, Birnbaum et al. demonstrate the surprisingly tight focus of such T cell cross-reactivity.
Medical subject headings
- Peptides
- Receptors, Antigen, T-Cell
- T-Lymphocytes