Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24856897.
- Also identified by DOI 10.1016/j.jcyt.2014.02.016.
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Abstract
Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS). We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls. Except for an increase in the number of C-C chemokine receptor 7-expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells. Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.
Medical subject headings
- Dendritic Cells
- Immunotherapy
- Lymphocyte Activation
- Multiple Sclerosis
- Receptors, CCR7