Manipulating the epigenome in germinal center lymphomas: is it getting easier and ezier?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24857928.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0629.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mutations affecting key epigenetic modifiers tend to cluster in malignancies in which cells of origin lie in the germinal center (GC). EZH2, as transcriptional repressor, is mutated in high frequency in Chinese and Western patients with follicular lymphoma and may represent a rational target for GC-derived lymphomas. .
Medical subject headings
- Epigenomics
- Germinal Center
- Lymphoma
- Mutation
- Polycomb Repressive Complex 2