FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 24857950.
- Also identified by DOI 10.1371/journal.pone.0098041 and PMC identifier 4032333.
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Abstract
In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.
Medical subject headings
- Colorectal Neoplasms
- DNA-Binding Proteins
- Proto-Oncogene Protein c-ets-1
- Signal Transduction
- Transcription Factors