Detection of a sexually transmitted hepatitis C virus protease inhibitor-resistance variant in a human immunodeficiency virus-infected homosexual man.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24859204.
- Also identified by DOI 10.1053/j.gastro.2014.05.010.
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Abstract
There is an international epidemic of hepatitis C virus (HCV) infection among human immunodeficiency virus-infected men who have sex with men. Transmission of HCV variants that are resistant to recently approved direct-acting antivirals (DAAs) could be an important clinical and public health problem. We document a case of transmission of a DAA-resistant variant of HCV from a patient who was treated with telaprevir to his sexual partner. The transmission of HCV DAA-resistant variants could impair therapeutic regimens that include DAAs.
Medical subject headings
- Antiviral Agents
- Coinfection
- Drug Resistance, Viral
- HIV Infections
- HIV-1
- Hepacivirus
- Hepatitis C
- Homosexuality, Male
- Protease Inhibitors