Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.

Howie, Stephen R C; Morris, Gerard A J; Tokarz, Rafal; Ebruke, Bernard E; Machuka, Eunice M; Ideh, Readon C; Chimah, Osaretin; Secka, Ousman et al. · Clin Infect Dis · 2014

case_series · Level IV

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Abstract

Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae.

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