Induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24873662.
- Also identified by DOI 10.1021/nl5002026 and PMC identifier 4055043.
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Abstract
We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis.
Medical subject headings
- Fibroblasts
- Lung
- Models, Biological
- Nanotubes, Carbon