Decrease of muscle volume in chronic kidney disease: the role of mitochondria in skeletal muscle.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24875545.
- Also identified by DOI 10.1038/ki.2013.539.
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Abstract
Reduced muscle volume and impaired exercise endurance are well-documented phenomena in chronic kidney disease, and the relevant molecular mechanisms have been gradually unveiled. Tamaki et al. demonstrate a reduction of mitochondria content in skeletal muscles as a novel mechanism of reduced exercise endurance in renal insufficiency. In addition, they show that a high-protein diet reduces exercise endurance through an inhibition of muscle pyruvate dehydrogenase.
Medical subject headings
- Dietary Proteins
- Exercise Tolerance
- Mitochondria, Muscle
- Mitochondrial Turnover
- Muscle, Skeletal
- Pyruvate Dehydrogenase Complex
- Renal Insufficiency, Chronic