TAF7L modulates brown adipose tissue formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24876128.
- Also identified by DOI 10.7554/eLife.02811 and PMC identifier 4066819.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification.
Medical subject headings
- Adipose Tissue, Brown
- Gene Expression Regulation
- Muscles
- PPAR gamma
- TATA-Binding Protein Associated Factors
- Transcription Factor TFIID