Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with β-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 24879786.
- Also identified by DOI 10.1093/cid/ciu409.
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Abstract
Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with β-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.
Medical subject headings
- B-Lymphocytes
- Epitopes, B-Lymphocyte
- Pneumococcal Infections
- Pneumococcal Vaccines
- Streptococcus pneumoniae
- beta-Thalassemia