Common variants of cGKII/PRKG2 are not associated with gout susceptibility.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 24882840.
- Also identified by DOI 10.3899/jrheum.131548.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. cGKII variants have no association with gout. Our replication study suggests that cGKII is not involved in gout susceptibility.
Medical subject headings
- Asian People
- Cyclic GMP-Dependent Protein Kinase Type II
- Genetic Predisposition to Disease
- Gout