Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24890678.
- Also identified by DOI 10.1002/adma.201401550 and PMC identifier 4292873.
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Abstract
A novel anti-cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug-loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor-affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.
Medical subject headings
- Breast Neoplasms
- Drug Carriers
- Mesenchymal Stem Cells
- Nanoparticles
- Photochemotherapy
- Photosensitizing Agents