The genetics and immunobiology of IgA nephropathy.
review · Level V
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- Record sourced from PubMed, PMID 24892706.
- Also identified by DOI 10.1172/JCI74475 and PMC identifier 4089454.
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Abstract
IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong genetic determination. This Review summarizes new insights into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.
Medical subject headings
- Glomerulonephritis, IGA