Prophylactic antibiotic therapy in chronic obstructive pulmonary disease.
systematic_review · Level I
Where this comes from
- Record sourced from PubMed, PMID 24893090.
- Also identified by DOI 10.1001/jama.2014.4929.
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Abstract
CLINICAL QUESTION Is prophylactic antibiotic treatment associated with fewer exacerbations or improved health-related quality of life (HRQOL) in patients with chronic obstructive pulmonary disease (COPD)? BOTTOM LINE Continuous macrolide antibiotic use for prophylaxis was associated with a clinically significant reduction in COPD exacerbations. Pulsed antibiotic use was not associated with benefit. Continuous and pulsed antibiotics were associated with improved HRQOL, but this was not clinically significant.
Medical subject headings
- Anti-Bacterial Agents
- Antibiotic Prophylaxis
- Disease Progression
- Pulmonary Disease, Chronic Obstructive
- Quality of Life