Getting pumped about heart failure.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24896535.
- Also identified by DOI 10.1016/j.cmet.2014.05.008 and PMC identifier 4105985.
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Abstract
Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.
Medical subject headings
- Heart Failure
- MicroRNAs
- Myocardial Contraction