IL-6 strikes a balance in metabolic inflammation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24896536.
- Also identified by DOI 10.1016/j.cmet.2014.05.009 and PMC identifier 4103792.
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Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine that exerts either proinflammatory or anti-inflammatory effects and is implicated in diverse settings, including obesity, exercise, arthritis, and colitis. A new study shows that modulation of macrophage activation by IL-6 maintains glucose homeostasis in diet-induced obesity while limiting inflammation in endotoxemia (Mauer et al., 2014).
Medical subject headings
- Endotoxemia
- Insulin Resistance
- Interleukin-6
- Macrophage Activation
- Macrophages
- Obesity