Lost in transition: dynamic enhancer organization across naive and primed stem cell states.
basic_science · Level V
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- Record sourced from PubMed, PMID 24905156.
- Also identified by DOI 10.1016/j.stem.2014.05.004 and PMC identifier 4115280.
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Abstract
Pluripotent stem cells transition between distinct naive and primed states that are controlled by overlapping sets of master regulatory transcription factors. In this issue of Cell Stem Cell, Buecker et al. (2014) and Factor et al. (2014) demonstrate that alternate enhancer usage, regulated by state-specific binding partners of master regulators, defines these pluripotent state transitions.