Stem cells go soft: pliant substrate surfaces enhance motor neuron differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24905160.
- Also identified by DOI 10.1016/j.stem.2014.05.007 and PMC identifier 4109975.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.
Medical subject headings
- Cell Differentiation
- Mechanotransduction, Cellular
- Motor Neurons
- Nuclear Proteins
- Pluripotent Stem Cells
- Protein Serine-Threonine Kinases
- Transcription Factors