Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24905161.
- Also identified by DOI 10.1016/j.stem.2014.05.016 and PMC identifier 4278638.
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Abstract
Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.
Medical subject headings
- Cyclic AMP-Dependent Protein Kinases
- Fasting
- Hematopoietic Stem Cells
- Immunosuppression Therapy
- Insulin-Like Growth Factor I
- Regeneration