Delivering three punches to knockout intracellular bacteria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24906142.
- Also identified by DOI 10.1016/j.cell.2014.05.023.
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Abstract
Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.
Medical subject headings
- Antigens, Differentiation, T-Lymphocyte
- Bacterial Infections
- Escherichia coli
- Leukocytes, Mononuclear
- Listeria monocytogenes
- Staphylococcus aureus