Getting a grip on piRNA cluster transcription.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24906143.
- Also identified by DOI 10.1016/j.cell.2014.05.022 and PMC identifier 4053829.
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Abstract
The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.
Medical subject headings
- Chromosomal Proteins, Non-Histone
- Drosophila Proteins
- Drosophila melanogaster
- Microtubule-Associated Proteins
- RNA Splicing
- RNA, Small Interfering
- RNA-Binding Proteins
- Transcription, Genetic