TP53 mutations and lung cancer: not all mutations are created equal.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24916693.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0899.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Mutation
- Prognosis
- Tumor Suppressor Protein p53