Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24916696.
- Also identified by DOI 10.1158/1078-0432.CCR-14-0821 and PMC identifier 4204112.
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Abstract
Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA.
Medical subject headings
- Antibiotics, Antineoplastic
- Cardiotoxicity
- DNA Damage
- DNA, Mitochondrial
- Doxorubicin
- Heart